Plague Inc. Revenge of Osiris Achievement Guide

To unlock the Revenge of Osiris achievement in Plague Inc., you must start a Necroa Virus outbreak in Egypt, wait for the multi-stage tomb excavation news chain to trigger the curse, and wipe out humanity with your zombie horde.

Recommended Setup

Playing on Casual or Normal difficulty prevents early cure research and aggressive border closures from disrupting the narrative event chain before the excavation finishes.

Equip the following genetic setup to accelerate early transmission while controlling DNA costs:

DNA Gene (ATP Boost): Grants bonus starting DNA to purchase opening transmission vectors immediately.
Travel Gene (Aquacyte): Improves spread across sea lanes from Egyptian ports to remote island targets.
Evolution Gene (Trans-Stasis): Prevents symptom costs from increasing as you evolve other traits.
Mutation Gene (Genetic Mimic): Increases the total work required to complete the cure.
Environment Gene (Extremophile): Boosts transmission across all climate types to aid spread out of Egypt's arid environment.

Initiating the Tomb Excavation Chain

Start your plague exclusively in Egypt; choosing any other country disables the required storyline entirely. Pop the starting red bubble and avoid mutating severe or lethal symptoms, which can prompt containment measures that halt archaeological work.

Evolve Saliva 1 and Gastrointestinal Expansion to establish reliable fluid transmission along the Nile basin.
Evolve Water 1 to expand local spread and fulfill the background conditions for archaeological headlines.
Monitor the top news banner between day 100 and day 200. If no headline about archaeologists working in Egypt appears before infection levels peak, restart the run.

Managing the Narrative Popups

After the storyline begins, keep severity low and evolve supporting transmission traits while the news flags advance through three stages.

Stage	News Event Banner	Action Required
Stage 1	Archaeologists search for ancient tomb in Egypt	Evolve Water 2 and Air 1; avoid high-severity symptoms.
Stage 2	Tomb of Osiris discovered in Egypt	Evolve Cold Resistance 1 and Heat Resistance 1; bank 25–40 DNA.
Stage 3	Hieroglyphs warn of Osiris' Revenge	Stop waiting; immediately start evolving zombification symptoms.

The appearance of the Hieroglyphs warn of Osiris' Revenge headline confirms that the prerequisite condition has been satisfied.

Zombification and Eradicating Z-Com

Once the warning headline appears, spend your banked DNA in the Symptoms menu along the direct path to reanimation:

Insomnia -> Fever -> Photophobia -> Delirium -> Cytopathic Reanimation

Cytopathic Reanimation raises your infected hosts into active zombies across Egypt and neighboring regions. To protect the horde and clear the map, evolve combat traits and active movement:

Evolve Anaerobic Resuscitation to reduce natural zombie decay over time.
Evolve Enhanced Motor Integration and Masticatory Tension to overpower civilian defense forces and increase combat lethality.
Unlock Horde Movement, Structured Travel, and Drifting Herd in the Abilities tree.
Use the Horde Movement active ability to target territories where Z-Com establishes bases before their fortification ratings reach 100%.
Direct remaining hordes into uninfected island nations, such as Greenland, Iceland, or Madagascar, if their ports have closed.

Wipe out all surviving Z-Com bases and reduce the global human population to zero. The Revenge of Osiris achievement will unlock on the final victory screen.