Plague Inc. Nano-Virus Mega Brutal Guide
To beat the Nano Virus on Mega Brutal in Plague Inc., delay major cure resets until research accelerates, reach all islands, and rush Total Organ Failure.
Plague Inc. Guides
The latest Plague Inc. guides.
Game Information
About Plague Inc.
Plague Inc. is a strategy simulation game about evolving a deadly pathogen, infecting the world, and adapting against humanity’s defenses. Its guide hub can organize practical information around pathogen evolution, global spread, and responses to defensive actions described in the game.
US App Store Rankings
Strategy Top Free #69Strategy Featured #6
Last Updated
Regional & Alternate Titles
Global / US / CNPlague Inc.
KRPlague Inc. (전염병 주식회사)
JPPlague Inc. -伝染病株式会社-
TWPlague Inc. (瘟疫公司)
Editorial Team
Maintained by AAYYY Editorial TeamReviewed by James Brown
Game information is refreshed when tracked chart data changes; guides are added as they are published.
Latest Guides
Plague Inc. Bio-Weapon Mega Brutal Fast Clear Guide
Harness rising Bio Weapon lethality in Plague Inc. to farm DNA, infect all nations before border lockdowns, and trigger the final lethal gene.
Plague Inc. Co-op Hard Mode: How to Play the Sacrificer
Win Plague Inc. Co op on Hard as the Sacrificer by drawing cure focus, opening island borders, and timing lab sabotage before lethal wipeouts.
Plague Inc.: How to Awaken and Control Multiple Vampires in Shadow Plague
Awaken secondary vampires in Plague Inc. by evolving Shadow Blessing after securing Blood Lairs and Therianthropy flight for safe recovery.
Plague Inc.: How Hidden Infection and Cure Mechanics Decide Runs
Bypass border closures and control cure progress in Plague Inc. by zeroing lethality early, prioritizing water spread, and countering wealth.
Plague Inc. Russian Nuclear Retaliation Achievement Guide
Unlock Russian Nuclear Retaliation in Plague Inc. by starting in the US, evolving Insanity without lethality, and infecting cold Russia.
Plague Inc.: Which Disease Can Beat the Game the Fastest?
The Neurax Worm beats Plague Inc. the fastest because Trojan Planes bypass border closures and Transcendence wins instantly upon full infection.
Plague Inc. Prion Strategy Guide: How to Beat the Hardest Plague
Win Plague Inc. on Prion by staying undetected with Water and Cold traits, delaying Neural Atrophy until 25% cure, and pivoting to Organ Failure.
Plague Inc.: How to Unlock All 3 Xenolith Secret Endings
Unlock each Xenolith secret ending in Plague Inc. by infecting the entire world at zero lethality before evolving the required narrative traits.
Plague Inc. Mega Brutal No Genes Strategy Guide
To beat Plague Inc. on Mega Brutal with no genes, start in Saudi Arabia, secure Water 2 early, and delay lethality until all islands are infected.
How to Beat the Greenland Airport Scenario in Plague Inc.
Plague Inc. Mad Cow Disease Mega Brutal 3 Biohazards Guide
Plague Inc. Revenge of Osiris Achievement Guide
Plague Inc. Asymptomatic Bio-Weapon Guide: How to Win Undetected
Plague Inc. Bacteria Mega Brutal Guide: How to Earn 5 Biohazards
Plague Inc. Nano-Virus Any% Speedrun Route and Strategy
Plague Inc. Shadow Plague: How to Win in Under 365 Days
Plague Inc. Parasite Guide: How to Win with Stealth and Symbiosis
Plague Inc. Fungus Mega Brutal Strategy Guide
Plague Inc.: How to Infect Greenland and Prevent Port Closures